Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?
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چکیده
منابع مشابه
Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia
OBJECTIVE Studies on children with Acute Lymphoblastic Leukemia (ALL) reported non-adherence in 2-54% of cases. The primary objective of this study was to assess rates of adherence to 6-MP using two different methods in children and adolescents with ALL. Secondary aim was to identify factors that influence adherence to 6-MP in children with ALL. METHODS All eligible children with ALL who are ...
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Acute lymphoblastic leukemia (ALL) accounts for nearly 30% of pediatric cancers. The maintenance treatment for ALL comprises daily oral 6-mercaptopurine (6-MP) and weekly methotrexate (MTX). 6-MP is a purine analog that can significantly improve the long-term survival of ALL patients. Despite more than 90% of 5-year survival of childhood ALL in developed countries, treatment interruption due to...
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MARKOWITZ, A.M. & KOONTZ, P. (1966) The development of colonic polyps at the site of ureteral implantation. Surgery, 60, 761. MARSHALL, S., LYON, R.P. & MINKLER, D. (1966) Ureteral dilatation following use of oral contraceptives. Journal of the American Medical Association, 198, 782. OETJEN, L.H., CAMPBELL, J.L., THOMLEY, M.W. & PARSONS, R.L. (1970) Carcinoma of the colon following ureterosigmo...
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Several 9-alkyl, 6-thiopurines have been reported to have more favorable therapeutic indexes than do the parent drugs, 6mercaptopurine (MP) and 6-thioguanine (TG). Some of these compounds were reported to be active against cells in culture resistant to 6-thiopurines, and it has been assumed that their mechanisms of action may differ from those of TG and MP. 9(n-Butyl)-6-thioguanine was essentia...
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The effects of 6-thioguanine on purine biosynthesis and cell viability have been examined in H.Ep. 2 cells grown in culture. Toxicity is not reversed by aminoimidazolecarboxamide, suggesting that inhibition of purine biosynthesis de novo is not the sole mechanism of toxicity. Also, 6-(methylmercapto)purine ribonucleoside, a potent inhibitor of purine biosynthesis de novo, produces more marked r...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1993
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1993.311